Proteomics is the study of proteins in the body. Medscape reported on a recently published study which showed that people with ME/CFS have “multiple maladaptive proteomic responses to exercise compared with matched sedentary controls.” In simpler terms, the study found changes on a biological basis, at the protein level in individuals with ME/CFS compared with healthy controls following exercise.
According to the Medscape article, “The new plasma profiling study focused on PEM … The authors assessed correlations of levels of 6361 unique proteins with patient-reported symptom data gathered before, during, and after 2 days of maximal cardiopulmonary exercise testing (CPET). Compared with 53 healthy people who were similarly sedentary — to control for the effects of deconditioning — 79 individuals with ME/CFS showed sustained immune, metabolic, and neuromuscular dysregulation following the first CPET.”
A validating quote from the article that stood out was – ‘“Fundamentally, the ME/CFS patient’s response to exercise is very different and very impaired….These are objective changes in the bodies of these patients that correspond with what the patients are saying,” study co-author Katherine A. Glass, PhD, research associate at Cornell University, Ithaca, New York, told Medscape Medical News.’
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