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Disrupted brain waste clearance in ME/CFS

The team at Griffith University is on a roll at the moment, and have recently published more findings that come out of their brain imaging research funded by ME Research UK over the last few years. This time they have turned their attention to the glymphatic system, which is responsible for clearing waste products from the brain.

Dr Kiran Thapaliya’s paper in Frontiers of Neuroscience reports that people with ME/CFS had dysfunction of the glymphatic system, which was associated with greater severity of symptoms, including sleep dysfunction and cognitive impairment.

The researchers suggest that impairment of the glymphatic system in ME/CFS may therefore contribute to the accumulation of waste products in the brain, leading to inflammation and resulting in neurological symptoms.

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