The following ME Research UK articles explore the possible links between Epstein-Barr Virus (EBV) and ME/CFS, including its possible role in triggering the disease, potential diagnostic markers, and insights from related conditions.
- Key facts about EBV and ME/CFS
Many individuals report glandular fever, which is caused by EBV, before their ME/CFS onset. Nevertheless, most people will be infected with EBV during their lifetime, but not everyone will develop symptoms, and even fewer go on to develop ME/CFS. Theories linking EBV to ME/CFS include viral reactivation, immune dysfunction, and genetic predisposition. - Young people with ME/CFS 1-year follow-up after glandular fever (EBV) infection
A study followed 25 young people diagnosed with ME/CFS after EBV infection for one year. All experienced severe limitations in daily activities, though there did appear to be some differences between age groups. - EBV-related antibodies and ME/CFS diagnosis
Researchers analysed antibody responses to more than 3000 EBV antigens (substances that trigger immune responses) in almost 100 ME/CFS patients. While no overall differences were found, patients with an infectious onset showed stronger responses to two EBV-related antigens. These findings require further confirmation. - Prevalence of viral cells in individuals with ME/CFS
A small study in Sweden investigated whether people with ME/CFS have higher levels of viral cells, including EBV, and links to immune exhaustion. - Insights from multiple sclerosis research
EBV is strongly linked with autoimmune diseases, including multiple sclerosis (MS). Some ME/CFS studies suggest abnormal immune responses to EBV, though findings remain inconclusive. Are there learning points that can be taken from MS research?
