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Abnormal breathing patterns identified in people with ME/CFS

Scientists have discovered that most people with chronic fatigue syndrome also struggle with hidden breathing problems. These abnormalities may intensify fatigue and could help explain why symptoms worsen after exertion” states an article published on the website ‘SciTechDaily’.

The SciTechDaily piece relates to a paper published in the journal ‘Frontiers in Medicine’ by a team of researchers, including Dr. Donna Mancini and Dr. Benjamin Natelson of Icahn School of Medicine. The scientists found that just under half of the 57 participants meeting the 2015 IOM case definition for ME/CFS displayed dysfunctional breathing patterns; this was significantly more than amongst the 25 healthy participants as shown in the table below.

57 people with ME/CFS 25 healthy controls Significant difference between those with ME/CFS and healthy controls?
Dysfunctional breathing 24 (42%)4 (16%)Yes
Hyperventilation18 people (32%)1 (4%)Yes
Both dysfunctional breathing and hyperventilation 9 (16%)0 (0%)not stated

Notably, 33 of the 57 patients with ME/CFS (58%) had either hyperventilation or dysfunctional breathing, this compared to only four of the 25 healthy controls (16%), demonstrating a significantly higher level of these respiratory abnormalities in the ME/CFS group.

The authors of the research suggest that although the diagnosis of dysfunctional breathing is challenging, based on the findings from their small study, breathing exercises – such as those used in yoga – may be beneficial for those with ME/CFS. Research is needed to assess how well these breathing retraining techniques work to reduce ME/CFS symptoms, and whether they might also improve exercise tolerance and reduce post exertional malaise.

infographic key points from the article. Text reads: 
-abnormal breathing patterns identified in people with ME/CFS 
-Compared with healthy controls, significantly more people with ME/CFS met criteria for ‘dysfunctional breathing’ patterns. 
-Based on the findings from the small study, breathing exercises may be beneficial for those with ME/CFS.

Research is needed to assess how well these breathing retraining techniques work to reduce ME/CFS symptoms, and to consider whether they might also improve exercise tolerance and reduce post exertional malaise. 
- Mancini et al., Frontiers in Medicine (2025)
-Inform influence invest
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Additionally, for illustrative purposes only, there is a small black and white image of a simplified person breathing
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