Brain connectivity differences distinguish between two classes of ME/CFS

Researchers Jiasheng Su, Kiran Thapaliya, Natalie Eaton-Fitch, Sonya Marshall-Gradisnik, Leighton Barnden Institution Griffith University, Australia Publication Brain Connectivity, 2023 April; 13(3):164–73 Funding ME Research UK funded Dr Su. The study was also supported by grants from various other research and charitable foundations. Abstract Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease with unknown […]

NIH ME/CFS Deep Phenotyping Study: Part 2. Methods

The US National Institutes of Health (NIH) intramural study on ME/CFS is a three-phase initiative to explore post-infectious ME/CFS in depth, and potentially to identify biomarkers and find treatments. The study was launched in 2016, and the first part, involving more than 70 researchers from a wide range of specialties, has just been completed after […]

World Sleep Day 2024

World Sleep Day, an annual event organised by the World Sleep Day Committee, aims to raise awareness about sleep-related issues and promote better prevention and management of sleep disorders. This year’s theme, ‘Sleep Equity for Global Health’, highlights that ‘sleep is essential to health, but measurable differences in sleep health persist across populations across the […]

Are ME/CFS and fibromyalgia indistinguishable?

While ME/CFS and fibromyalgia have overlapping symptoms – including cognitive difficulties, sleep problems, and fatigue, research has identified underlying biological differences between the two diseases. Despite this, a recently published article – in the title at least, suggests that “ME/CFS and fibromyalgia are indistinguishable” when looking at the proteins in the fluid that surrounds the […]

Estimating ME/CFS prevalence in individuals with long COVID

Key points Background During the early phases of the COVID-19 pandemic, as the term ‘long COVID’ first emerged, Dr Anthony Komaroff raised a crucial question in an article: “Will some people who get COVID-19 subsequently develop ME/CFS?” He further stated, “After all, many people with ME/CFS say that their illness began with some kind of infection: a virus, […]

The gut microbiome in people with severe ME/CFS

The relationship between the microbiome and the immune system in ME/CFS has been getting more and more attention. The microbiome comprises trillions of microbes largely residing in the gut, and it plays a pivotal role in health and disease. But, despite its significance, further exploration is needed to understand whether the microbiome is involved in the development […]

Do viruses cause ME/CFS – what does the evidence say?

Recently, ME Research UK summarised an article by Professor Maureen Hanson about the viral origins of ME/CFS. Viruses are tiny non-living microbes made up of genetic material – either two strands (deoxyribonucleic acid [DNA]) or a single strand (ribonucleic acid [RNA]) – inside a protein shell. Sometimes they also have an outer layer of fat molecules; those with […]

Differences between men & women with ME/CFS –  what does the evidence say?

Even in the absence of disease, there are differences between males and females in the way their bodies work – physiological differences. These are hugely important in explaining the variations in susceptibility to disease, and the disparity in response to medication and treatment. For example, a recent paper summarises that the sex hormones, oestrogen and testosterone, have different impacts […]

Can a brief screening scale accurately detect ME/CFS?

Key messages Introduction Without an operationalised diagnostic biomarker for ME/CFS, the illness is identified based on the presence of certain symptoms – in the absence of another disease that would explain them – using case definitions such as the Canadian Consensus Criteria (CCC), Fukuda criteria and the International Consensus Criteria (ICC) for ME/CFS, CFS and ME, respectively. It […]

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