IOM 2015 Criteria for ME/CFS

In 2015, the Institute of Medicine (IOM), now the National Academy of Medicine (NAM), published clinical criteria for diagnosing ME/CFS. According to the committee responsible, these criteria “focus more on the central symptoms of this disease than many other definitions” yet “are quite similar to the Canadian Consensus Criteria (CCC).” The committee also acknowledged that […]

NICE 2021 Criteria for ME/CFS

In 2021, NICE (National Institute for Health and Care Excellence) published a guideline for diagnosing and managing cases of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). This guideline replaced the NICE 2007 guideline, and key changes included: Summary of NICE 2021 Criteria To diagnose ME/CFS, all of the following symptoms should be present for at least 3 […]

International Consensus Criteria (ICC) for ME

Published in 2011, the International Consensus Criteria (ICC) is a set of diagnostic criteria used for identifying cases of myalgic encephalomyelitis (ME) for research and clinical purposes. Whilst based on the Canadian Consensus Criteria (CCC), significant changes were made to create a far more selective set of criteria. One interesting difference is the removal of the 6-month waiting period before […]

Canadian Consensus Criteria (CCC) and Revised CCC for ME/CFS

Published in 2003, the Canadian Consensus Criteria (CCC) is a set of diagnostic criteria used for identifying cases of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) for research and clinical purposes. It is also known as the clinical working case definition. In 2010, the CCC was revised to help clinicians and researchers better use the criteria and improve diagnostic […]

Fukuda criteria for CFS

The Fukuda criteria are used for identifying cases of chronic fatigue syndrome (CFS) for research purposes. They are also known as the CDC 1994 criteria as they were developed in conjunction with the US Centers for Disease Control and Prevention (CDC) in 1994. Although the CDC has now adopted newer criteria, the Fukuda criteria are […]

Committee to examine clinical diagnostic criteria

The US Department of Health and Human Services has announced * (by a Special Notice referenced under Solicitation 13-233-SOL-00686)  that it is to provide funding, via the National Academies (Institute of Medicine), to “support a study committee to recommend clinical diagnostic criteria” for ME/CFS.  The study committee, which will be made up of ‘thought leaders’ and […]

The specificity of the CDC-1994 criteria for chronic fatigue syndrome: comparison of health status in three groups of patients who fulfil the criteria

Authors Kennedy G, Abbot NC, Spence V, Underwood C, Belch JJF Institution Vascular Diseases Research Unit, The Institute of Cardiovascular Research, Ninewells Hospital and Medical School, Dundee, UK Support This study was supported by a grant from ME Research UK, and by the Sir John Fisher Foundation. Aim The Centers for Disease Control (CDC)-1994 definition of chronic […]

“Nearly half of chronic fatigue patients test positive for Bartonella or Babesia infection” finds small pilot study.

An article in Medical Press, which reports on developments in medical research, discussed early-stage findings published in the journal Pathogens indicating that nearly half of patients with chronic fatigue tested positive for Bartonella or Babesia infections.  Babesia and Bartonella are often suspected as co-infections with Lyme disease which, as discussed in previous ME Research UK articles, is caused by the bacteria Borrelia burgdorferi, transmitted through the bite of an infected tick.  In the research paper, the authors highlight the overlap in […]

Heightened antibody responses to herpesviruses in females with ME/CFS

A recent study analysed over 800 blood samples from 40 females with ME/CFS compared to 16 healthy controls. The study primarily examined differences in antibodies to human herpesvirus proteins, and it found that participants with ME/CFS exhibited significantly altered antibody levels (indicating viral reactivation) compared to controls. Study Caveats Important considerations to be noted: Study […]

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