Authors

Newton JL, Sheth A, Shin J, Pairman J, Wilton K, Burt JA, Jones DEJ

Institution

Cardiovascular Investigation Unit, Institute of Cellular Medicine, Newcastle University, Newcastle, UK

Objective

To examine blood pressure circadian rhythm in subjects with chronic fatigue syndrome (CFS) and appropriate normal and fatigued controls to correlate parameters of blood pressure regulation with perception of fatigue in an observational cohort study. The cause of CFS remains unknown and there are no effective treatments.

Methods

To address whether inactivity was a confounder, we performed a 24-hour ambulatory blood pressure monitoring in the following three subject groups: 1) CFS patients (Fukuda Diagnostic criteria) (n=38); 2) normal controls (n=120); and 3) a fatigue comparison group (n=47) with the autoimmune liver disease primary biliary cirrhosis (PBC). All patients completed a measure of fatigue severity (Fatigue Impact Scale). In view of the different demographics between the patient groups, patients were age- and sex-matched on a case-by-case basis to normal controls and blood pressure parameters were compared.

Results

Compared with the control population, the CFS group had significantly lower systolic blood pressure (p<0.0001) and mean arterial blood pressure (p=0.0002) and exaggerated diurnal variation (p=0.009). There was a significant inverse relationship between increasing fatigue and diurnal variation of blood pressure in both the CFS and PBC groups (p<0.05).

Conclusion

Lower blood pressure and abnormal diurnal blood pressure regulation occur in patients with CFS. We would suggest the need for a randomized, placebo-controlled trial of agents to increase blood pressure such as midodrine in CFS patients with an autonomic phenotype.

Publication

Psychosomatic Medicine, 2009 Apr; 71(3): 361–5