There’s an interesting background piece on Phoenix Rising , based on Prof Stephen Holgate’s presentation to the Forward ME group at the House of Lords a few weeks ago. It covers a range of issues, including his belief that ME/CFS could have twelve to fifteen different “causal pathways”.
Importantly, the essay links to a viewpoint article originally published in ‘Nature Reviews: Neuroscience’ in 2011 which – though long and covering a myriad of topics – is still well worth a serious read. In it, Prof Holgate points out the problem of the low-quality scientific evidence base of ME/CFS, and the lack of research capacity (i.e. funded research groups dedicated to working on the illness) – serious problems that we all recognise and want to see overcome.