Experiments with laser-evoked potentials and cerebral blood flow
There is now good evidence of hypersensitivity of the central nervous system – called central sensitization – in ME/CFS patients. However, direct monitoring of brain responses to harmful (noxious) stimuli has never been performed in patients with ME/CFS, and such direct evidence of central sensitization is crucial if the scientific world is to be persuaded.
For this reason, ME Research UK has funded a consortium of researchers specialising in neurology, cardiology and rehabilitation at Vrije Universiteit Brussel – led by Prof. Jo Nijs who has been at the forefront of ME/CFS investigation for a number of years – to undertake two related studies. Both aim to unravel the abnormal response of people with ME/CFS to exercise and, specifically, the inability of the brain of these patients to activate pain inhibition during and after physical activity.