A hallmark of ME/CFS is that symptoms are made worse by exercise, sometimes 24-48 hours afterwards, even if the exercise is quite mild by normal standards. Dr David Patrick and colleagues at the University of British Columbia in Canada are examining post-exercise symptoms of patients using newly available gene sequencing technologies that allow a much deeper probe of host gene expression than has previously been possible.
The National Institutes of Health in the US has funded most of the work involving RNA sequencing of samples, and ME Research UK’s funding will allow additional measurements of mRNA expression up to 7 days after exercise. The research group hopes to identify specific gene expression patterns or responses in ME/CFS patients that might explain prolonged post-exercise symptoms.
Read more at the specific project page, Host gene expression during post-exertional symptom flare in ME/CFS