Over the past decade, ME Research UK-funded researchers at the Vascular & Inflammatory Diseases Research Unit, University of Dundee have discovered a range of biological abnormalities in ME/CFS patients, including high levels of apoptotic (dying) white blood cells and increased arterial stiffness. But their main finding has been that people with ME/CFS have high levels of oxidative stress, which can harm blood vessels and muscles.
It is important to discover the origin of oxidative stress so that ways of counteracting cardiovascular damage can be developed. For this reason, we have awarded further funding to the research team in Dundee to investigate the role of “Nrf2”, one of the master activators of the body’s natural defence against oxidative stress.
See the story: Combatting Oxidative Stress