Research papers
These are research papers published to date from projects funded by ME Research UK.
Select a title from the list to download a pdf of the paper or read an abstract of the article. Some of these link to external websites.
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Perceived fatigue is comparable between different disease groups
Jones DEJ, Gray JC, Newton JL. Quarterly Journal of Medicine 2009; 102(9): 617–24. (abstract)
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Plasma IL-6, its soluble receptors and F-isoprostanes at rest and during exercise in chronic fatigue syndrome
Robinson M, Gray SR, Watson MS, Kennedy G, Hill A, Belch JJ, Nimmo MA. Scandinavian Journal of Medicine in Science and Sports 2009; epub. (abstract)
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An in vivo proton neurospectroscopy study of cerebral oxidative stress in myalgic encephalomyelitis (chronic fatigue syndrome)
Puri BK, Agour M, Gunatilake KD, Fernando KA, Gurusinghe AI, Treasaden IH. Prostaglandins, Leukotrienes and Essential Fatty Acids 2009; 81(5–6): 303–5. (abstract)
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Lower ambulatory blood pressure in chronic fatigue syndrome
Newton JL, Sheth A, Shin J, Pairman J, Wilton K, Burt JA, Jones DE. Psychosomatic Medicine 2009; 71(3): 361–5. (abstract)
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A gene signature for post-infectious chronic fatigue syndrome
Gow JW, Hagan S, Herzyk P, Cannon C, Behan PO, Chaudhuri A. BMC Medical Genomics 2009; 2: 38.
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Pilot study of peripheral muscle function in primary biliary cirrhosis: potential implications for fatigue pathogenesis
Hollingsworth KG, Newton JL, Taylor R, McDonald C, Palmer JM, Blamire AM, Jones DE. Clinical Gastroenterology and Hepatology 2008; 6(9): 1041–8. (abstract)
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Postural orthostatic tachycardia syndrome is an under-recognized condition in chronic fatigue syndrome
Hoad A, Spickett G, Elliott J, Newton J. Quarterly Journal of Medicine 2008; 101: 961–5. (pdf 77 KB)
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Low grade inflammation and arterial wave reflection in patients with chronic fatigue syndrome
Spence VA, Kennedy G, Belch JJF, Hill A, Khan F. Clinical Science 2007; 114: 561–6. (abstract)
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Symptoms of autonomic dysfunction in chronic fatigue syndrome
Newton JL, Okonkwo O, Sutcliffe K, Seth A, Shin J, Jones DEJ. Quarterly Journal of Medicine 2007; 100: 519–26. (pdf 120 KB)
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Is chronic fatigue syndrome associated with platelet activation?
Kennedy G, Norris G, Spence VA, McLaren M, Belch JJF. Blood Coagulation and Fibrinolysis 2006; 17: 89–92. Lippincott Williams and Wilkins. (abstract)
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Chronic fatigue syndrome
Abbot NC, Spence VA. Lancet 2006; 367: 1574. (full text, free but requires registration)
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Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms
Kennedy G, Spence VA, McLaren M, Hill A, Underwood C, Belch JJF. Free Radical Biology and Medicine 2005; 39(5): 584–9. (abstract)
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Acetylcholine mediated vasodilatation in the microcirculation of patients with chronic fatigue syndrome
Spence VA, Khan F, Kennedy G, Abbot NC, Belch JJF. Prostaglandins, Leukotrienes and Essential Fatty Acids 2004; 70: 403–7. (abstract)
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Standing up for ME: Cardiovascular mechanisms of orthostatic intolerance
Spence VA, Stewart JM. The Biologist 2004; 51(2): 65–70. (pdf 144 KB)
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Increased neutrophil apoptosis in chronic fatigue syndrome
Kennedy G, Spence VA, Underwood C, Belch JJF. Journal of Clinical Pathology 2004; 57: 891–3. (abstract)
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Plasma endothelin-1 levels in chronic fatigue syndrome (letter)
Kennedy G, Spence V, Khan F, Belch JJF. Rheumatology 2004; 43: 252–3. (full article)
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Peripheral cholinergic function in humans with chronic fatigue syndrome, Gulf War syndrome, and with illness following organophosphate exposure
Khan F, Kennedy G, Spence VA, Newton DJ, Belch JJF. Clinical Science 2004; 106: 183–9. (pdf 104 KB)
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The specificity of the CDC-1994 criteria for chronic fatigue syndrome: comparison of health status in three groups of patients who fulfil the criteria
Kennedy G, Abbot NC, Spence V.A, Underwood C, Belch JJF. Annals of Epidemiology 2004; 14: 95–100. (abstract)
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Prolonged acetylcholine-induced vasodilatation in the peripheral microcirculation of patients with chronic fatigue syndrome
Khan F, Spence VA, Kennedy G, Belch JJF. Clinical Physiology and Functional Imaging 2003; 23: 282–5. (pdf 59 KB)
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Increased plasma isoprostanes and other markers of oxidative stress in chronic fatigue syndrome
Kennedy G, Spence VA, McLaren M, Hill A, Belch JJF. Journal of Thrombosis and Haemostasis 2003; 1(Suppl 1): P0182. (abstract)
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Cognitive behaviour therapy for chronic fatigue syndrome
Spence VA, Abbot NC. Lancet 2001; 358: 239–40. (full text, free but requires registration)
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Enhanced sensitivity of the peripheral cholinergic vascular response in patients with chronic fatigue syndrome
Spence VA, Khan K, Belch JJF. American Journal of Medicine 2000; 108: 736–9. (pdf 100 KB)
